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Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application

Paper ID Volume ID Publish Year Pages File Format Full-Text
37523 45365 2010 9 PDF Available
Title
Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application
Abstract

Elastin-like polypeptides (ELPs) are highly biocompatible and exhibit a potentially highly useful property: that of a thermally responsive reversible phase transition. These characteristics make ELPs attractive for drug delivery, appealing as materials for tissue repair or engineering, and improve the efficiency with which recombinant proteins can be purified. ELP fusion proteins (referred to as ELPylation) inherit the reversible phase transition property. ELPylation technology recently has been extended to plant cells, and a number of plant-based expression systems have been evaluated for the production of ELPylated proteins. Here, we discuss recent developments in ELP technology and the substantial potential of ELPs for the deployment of transgenic plants as bioreactors to synthesize both biopharmaceuticals and industrial proteins.

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Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 1, January 2010, Pages 37–45
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us