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Enzyme engineering for enantioselectivity: from trial-and-error to rational design?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37524 45365 2010 9 PDF Available
Title
Enzyme engineering for enantioselectivity: from trial-and-error to rational design?
Abstract

The availability of tailored enzymes is crucial for the implementation of biocatalysis in organic chemistry. Enantioselectivity is one key parameter defining the usefulness of an enzyme and, therefore, the competitiveness of the corresponding industrial process. Hence, identification of enzymes with high enantioselectivity in the desired transformation is important. Currently, this is achieved by screening collections and libraries comprising natural or man-made diversity for the desired trait. Recently, a variety of improved methods have been developed to generate and screen this diversity more efficiently. Here, we present and discuss the most important advances in both library generation and screening. We also evaluate future trends, such as moving from random evolution to more rational.

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Enzyme engineering for enantioselectivity: from trial-and-error to rational design?
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 1, January 2010, Pages 46–54
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us