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Rational drug design via intrinsically disordered protein

Paper ID Volume ID Publish Year Pages File Format Full-Text
37527 45366 2006 8 PDF Available
Title
Rational drug design via intrinsically disordered protein
Abstract

Despite substantial increases in research funding by the pharmaceutical industry, drug discovery rates seem to have reached a plateau or perhaps are even declining, suggesting the need for new strategies. Protein–protein interactions have long been thought to provide interesting drug discovery targets, but the development of small molecules that modulate such interactions has so far achieved a low success rate. In contrast to this historic trend, a few recent successes raise hopes for routinely identifying druggable protein–protein interactions. In this Opinion article, we point out the importance of coupled binding and folding for protein–protein signalling interactions generally, and from this and associated observations, we develop a new strategy for identifying protein–protein interactions that would be particularly promising targets for modulation by small molecules. This novel strategy, based on intrinsically disordered protein, has the potential to increase significantly the discovery rate for new molecule entities.

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Rational drug design via intrinsically disordered protein
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 10, October 2006, Pages 435–442
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us