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Chemical mapping of tumor progression by FT-IR imaging: towards molecular histopathology

Paper ID Volume ID Publish Year Pages File Format Full-Text
37530 45366 2006 8 PDF Available
Title
Chemical mapping of tumor progression by FT-IR imaging: towards molecular histopathology
Abstract

Fourier-transform infrared (FT-IR) spectro-imaging enables global analysis of samples, with resolution close to the cellular level. Recent studies have shown that FT-IR imaging enables determination of the biodistribution of several molecules of interest (carbohydrates, lipids, proteins) for tissue analysis without pre-analytical modification of the sample such as staining. Molecular structure information is also available from the same analysis, notably for protein secondary structure and fatty acyl chain peroxidation level. Thus, several cancer markers can be identified from FT-IR tissue images, enabling accurate discrimination between healthy and tumor areas. FT-IR imaging applications are now able to provide unique chemical and morphological information about tissue status. With the fast image acquisition provided by modern mid-infrared imaging systems, it is now envisaged to analyze cerebral tumor exereses in delays compatible with neurosurgery. Accordingly, we propose to take FT-IR imaging into consideration for the development of new molecular histopathology tools.

First Page Preview
Chemical mapping of tumor progression by FT-IR imaging: towards molecular histopathology
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 10, October 2006, Pages 455–462
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering