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From complete genome sequence to ‘complete’ understanding?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37535 45367 2010 9 PDF Available
From complete genome sequence to ‘complete’ understanding?

The rapidly accumulating genome sequence data allow researchers to address fundamental biological questions that were not even asked just a few years ago. A major problem in genomics is the widening gap between the rapid progress in genome sequencing and the comparatively slow progress in the functional characterization of sequenced genomes. Here we discuss two key questions of genome biology: whether we need more genomes, and how deep is our understanding of biology based on genomic analysis. We argue that overly specific annotations of gene functions are often less useful than the more generic, but also more robust, functional assignments based on protein family classification. We also discuss problems in understanding the functions of the remaining ‘conserved hypothetical’ genes.

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From complete genome sequence to ‘complete’ understanding?
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 8, August 2010, Pages 398–406
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Physical Sciences and Engineering Chemical Engineering Bioengineering