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Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
37543 45368 2009 10 PDF Available
Title
Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering
Abstract

There have been extensive research efforts to develop new strategies for bone tissue engineering. These have mainly focused on vascularization during the development and repair of bone. It has been hypothesized that pre-seeding a scaffold with endothelial cells could improve angiogenesis and bone regeneration through a complex dialogue between endothelial cells and bone-forming cells. Here, we focus on the paracrine signals secreted by both cell types and the effects they elicit. We discuss the other modes of cell-to-cell communication that could explain their cell coupling and reciprocal interactions. Endothelial cell-derived tube formation in a scaffold and the dialogue between endothelial cells and mesenchymal stem cells provide promising means of generating vascular bone tissue-engineered constructs.

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Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 10, October 2009, Pages 562–571
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us