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Potential of immunomodulatory host defense peptides as novel anti-infectives

Paper ID Volume ID Publish Year Pages File Format Full-Text
37545 45368 2009 9 PDF Available
Title
Potential of immunomodulatory host defense peptides as novel anti-infectives
Abstract

A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. Antimicrobial host defense peptides have been investigated for their potential as a new class of antimicrobial drugs. Recently their immunomodulatory activities have begun to be appreciated. Modulation of innate immunity by synthetic variants of host defense peptides, called innate defense regulators (IDRs), is protective without direct antimicrobial action. We discuss the potential and current limitations in exploiting the immunomodulatory activity of IDRs as a novel anti-infective pathway. IDRs show significant promise and current research is uncovering mechanistic information that will aid in the future development of IDRs for clinical use.

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Potential of immunomodulatory host defense peptides as novel anti-infectives
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 10, October 2009, Pages 582–590
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering