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Foreign protein degradation and instability in plants and plant tissue cultures

Paper ID Volume ID Publish Year Pages File Format Full-Text
37556 45369 2006 7 PDF Available
Title
Foreign protein degradation and instability in plants and plant tissue cultures
Abstract

Low production cost is a key factor driving the development of plants and plant tissue cultures for the synthesis of therapeutic and other foreign proteins. Because product yield and concentration exert a major influence on process economics, improving foreign protein accumulation is crucial for enhancing the commercial success of plant-based production systems. Strategies aimed at increasing transgene expression have been effective; however, a critical but poorly understood factor contributing to low foreign protein yield is post-synthesis and/or post-secretion instability and degradation. Loss of foreign protein as result of biological and physical processes such as proteolytic destruction and irreversible surface adsorption can occur in plants and plant culture systems. This review highlights the need to consider such mechanisms and outlines a range of remedial strategies aimed at minimizing foreign protein degradation and loss.

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Foreign protein degradation and instability in plants and plant tissue cultures
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 9, September 2006, Pages 426–432
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us