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The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities

Paper ID Volume ID Publish Year Pages File Format Full-Text
37560 45370 2007 10 PDF Available
Title
The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities
Abstract

The use of cytochrome P450 (P450 or CYP) enzymes as biocatalysts for the production of fine chemicals, including pharmaceuticals, has been of increasing interest, primarily owing to their catalytic diversity and broad substrate range. CYP102A1 (P450 BM3) from Bacillus megaterium integrates an entire monooxygenase system into one polypeptide and represents an appropriate prokaryotic model for industrial applications of mammalian P450 activities. CYP102A1 not only exhibits the highest catalytic activity ever detected in a P450 monooxygenase but also provides a potentially versatile biocatalyst for the production of human P450 metabolites. CYP102A1 can be further engineered to be a drug-metabolizing enzyme, making it a promising candidate to use as a biocatalyst in drug discovery and synthesis.

First Page Preview
The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 25, Issue 7, July 2007, Pages 289–298
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering