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The potential of oligonucleotides for therapeutic applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
37571 45371 2006 8 PDF Available
Title
The potential of oligonucleotides for therapeutic applications
Abstract

Viral-derived particles have been widely used and described in gene therapy clinical trials. Although substantial results have been achieved, major safety issues have also arisen. For more than a decade, oligonucleotides have been seen as an alternative to gene complementation by viral vectors or DNA plasmids, either to correct the genetic defect or to silence gene expression. The development of RNA interference has strengthened the potential of this approach. Recent clinical trials have also tested the ability of aptamer molecules and decoy oligonucleotides to sequestrate pathogenic proteins. Here, we review the potential of oligonucleotides in gene therapy, outline what has already been accomplished, and consider what remains to be done.

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The potential of oligonucleotides for therapeutic applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 12, December 2006, Pages 563–570
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us