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Towards a ‘universal’ nucleant for protein crystallization

Paper ID Volume ID Publish Year Pages File Format Full-Text
37580 45372 2009 8 PDF Available
Towards a ‘universal’ nucleant for protein crystallization

The expression ‘crystal clear’ stems from the science of crystallography, which determines the detailed atomic structures of materials by exposing crystals to X-rays. Protein structures are pivotal to the success of rational drug design and other biotechnology applications; however, obtaining high quality crystals poses a major problem to progress. Nucleation is the first step that determines the entire crystallization process, thus control of crystal nucleation would tackle the problem at its conception. A search for a ‘universal’ nucleant, a substance that can induce nucleation of any protein, is therefore on-going. We report the advances that have been made in this area, highlighting the success of especially engineered as well as naturally structured surfaces.

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Towards a ‘universal’ nucleant for protein crystallization
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 2, February 2009, Pages 99–106
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Physical Sciences and Engineering Chemical Engineering Bioengineering