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The silent treatment: RNAi as a defense against virus infection in mammals

Paper ID Volume ID Publish Year Pages File Format Full-Text
37592 45373 2006 8 PDF Available
Title
The silent treatment: RNAi as a defense against virus infection in mammals
Abstract

RNA interference (RNAi) is a mechanism for sequence-specific gene silencing guided by double-stranded RNA. In plants and insects it is well established that RNAi is instrumental in the response to viral infections; whether RNAi has a similar function in mammals is under intense investigation. Recent studies to address this question have identified some unanticipated interactions between the RNAi machinery and mammalian viruses. Furthermore, introduction of virus-specific small interfering RNAs (siRNAs) into cells, thus programming the RNAi machinery to target viruses, is an effective therapeutic approach to inhibit virus replication in vitro and in animal models. Although several issues remain to be addressed, such as delivery and viral escape, these findings hold tremendous potential for the development of RNAi-based antiviral therapeutics.

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The silent treatment: RNAi as a defense against virus infection in mammals
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 4, April 2006, Pages 186–193
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us