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Copy-number variation: the end of the human genome?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37596 45374 2009 7 PDF Available
Title
Copy-number variation: the end of the human genome?
Abstract

Copy-number variation (CNV) – the presence of additional or missing segments of chromosomes in some individuals – has been found to be abundant in humans and adds another dimension of variation to the genome. Copy-number variants have already been associated with some diseases and disease susceptibilities and are likely to prove as significant as sequence polymorphisms in this respect. Changes in copy number of parts of the genome are known to be a feature of many cancers, and their analysis is expected to reveal genes involved in carcinogenesis. This article will present a somewhat biased and occasionally speculative discussion of the current and future significance of CNV with a particular focus on the potential of molecular copy-number counting in the analysis of small, damaged or heterogeneous samples.

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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 8, August 2009, Pages 448–454
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us