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New light for science: synchrotron radiation in structural medicine

Paper ID Volume ID Publish Year Pages File Format Full-Text
37634 45378 2006 9 PDF Available
Title
New light for science: synchrotron radiation in structural medicine
Abstract

Macromolecular crystallography (MX) is a powerful method for obtaining detailed three-dimensional structural information about macromolecules. MX using synchrotron X-rays has contributed, significantly, to both fundamental and applied research, including the structure-based design of drugs to combat important diseases. New third-generation synchrotrons offer substantial improvements in terms of quality and brightness of the X-ray beams they produce. Important classes of macromolecules, such as membrane proteins (including many receptors) and macromolecular complexes, are difficult to obtain in quantity and to crystallise, which has hampered analysis by MX. Intensely bright X-rays from the latest synchrotrons will enable the use of extremely small crystals, and should usher in a period of rapid progress in resolving these previously refractory structures.

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New light for science: synchrotron radiation in structural medicine
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 11, November 2006, Pages 500–508
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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