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Overcoming acetate in Escherichia coli recombinant protein fermentations

Paper ID Volume ID Publish Year Pages File Format Full-Text
37638 45378 2006 7 PDF Available
Title
Overcoming acetate in Escherichia coli recombinant protein fermentations
Abstract

Escherichia coli is the organism of choice for the expression of a wide variety of recombinant proteins for therapeutic, diagnostic and industrial applications. E. coli generates acetic acid (acetate) as an undesirable by-product that has several negative effects on protein production. Various strategies have been developed to limit acetate accumulation or reduce its negative effects to increase the productivity of recombinant proteins. This article reviews recent strategies for reducing or eliminating acetate, including approaches that optimize the protein production process as well as those that involve modifying the host organism itself.

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Overcoming acetate in Escherichia coli recombinant protein fermentations
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 11, November 2006, Pages 530–536
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us