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Designer adenoviruses for nanomedicine and nanodiagnostics

Paper ID Volume ID Publish Year Pages File Format Full-Text
37662 45381 2009 10 PDF Available
Title
Designer adenoviruses for nanomedicine and nanodiagnostics
Abstract

With the recent explosion of interest in the field of nanobiotechnology, viruses are now finding new applications in materials science and medicine. Here, we discuss the engineering of ‘smart’ nanoparticles that are based upon recombinant adenovirus (Ad) vectors and that combine multiple functions of targeting, imaging and drug delivery. We focus on the use of Ads as a carrier and delivery system for macromolecules other than DNA and develop the rationale behind using Ads for such applications. Due to the modular nature of the Ad capsid, multiple therapeutic or diagnostic modalities, such as the addition of magnetic resonance imaging contrast agents, radiation sensitizers and antigenic peptides for vaccines, can be incorporated by modifying different sites on the viral capsid. These types of particles have a tremendous potential to increase the sensitivity and specificity of therapies.

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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 4, April 2009, Pages 220–229
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us