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Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing

Paper ID Volume ID Publish Year Pages File Format Full-Text
37664 45381 2009 8 PDF Available
Title
Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing
Abstract

The therapeutic use of proteins has created an increasing demand for feasible and economical methods for both up- and downstream processes. However, whereas upstream processes have attracted substantial investment and commercial attention, downstream processing has been overlooked, causing a production bottleneck that is shifting the costs of production. This review focuses on the use of aqueous two-phase extraction as an option for the downstream processing of therapeutic proteins. It is a potential and promising liquid–liquid extraction technique for the purification of biomolecules, such as monoclonal antibodies, growth factors and hormones, that combines a high selectivity and biocompatibility with an easy scale-up and continuous operation mode.

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Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 4, April 2009, Pages 240–247
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us