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Phenoxazinone synthase: what's in a name?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37665 45381 2009 11 PDF Available
Title
Phenoxazinone synthase: what's in a name?
Abstract

The name phenoxazinone synthase (PHS, 2-aminophenol:oxygen oxidoreductase, EC 1.10.3.4) is used for the enzyme catalysing the oxidative coupling of substituted o-aminophenols to produce phenoxazinones. This review reveals that the traditional classification of PHS conflicts with recent sequence-based information that shows its relationship with two distinct copper protein groups. Different PHS roles, namely spore pigmentation in Streptomyces antibioticus (phsA) and biosynthesis of the antibiotic grixazone in Streptomyces griseus subsp. griseus (GriF), indicate an example of convergent evolution. Here, we review the classification, distribution and roles of PHSs, comparing them with copper oxidases at genetic and structural levels and exploring their potential application in the production of new antibiotics.

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Phenoxazinone synthase: what's in a name?
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 4, April 2009, Pages 248–258
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering