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Artificial molecular sieves and filters: a new paradigm for biomolecule separation

Paper ID Volume ID Publish Year Pages File Format Full-Text
37700 45390 2008 10 PDF Available
Title
Artificial molecular sieves and filters: a new paradigm for biomolecule separation
Abstract

Patterned regular sieves and filters with comparable molecular dimensions hold great promise as an alternative to conventional polymeric gels and fibrous membranes to improve biomolecule separation. Recent developments of microfabricated nanofluidic sieves and filters have demonstrated superior performance for both analytical and preparative separation of various physiologically relevant macromolecules, including proteins. The insights gained from designing these artificial molecular sieves and filters, along with the promising results gathered from their first applications, serve to illustrate the impact that they can have on improving future separation of complex biological samples. Further development of artificial sieves and filters with more elaborate geometrical constraints and tailored surface functionality is believed to provide more promising ideals and results for biomolecule separation, which has great implications for proteomic research and biomarker discovery.

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Artificial molecular sieves and filters: a new paradigm for biomolecule separation
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 26, Issue 6, June 2008, Pages 311–320
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering