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DNA topoisomerase V: a new fold of mysterious origin

Paper ID Volume ID Publish Year Pages File Format Full-Text
37705 45395 2006 3 PDF Available
Title
DNA topoisomerase V: a new fold of mysterious origin
Abstract

Although all other topoisomerases have a broad phylogenetic distribution, DNA topoisomerase V, the major component of the ThermoFidelase sequencing kit, is presently only known in a single species – the archaeon Methanopyrus kandleri. Resolution of the structure of this enzyme by Taneja and co-workers now reveals that this atypical topoisomerase has no structural similarity with other proteins. So, where did it come from? It is my contention that Topo V, and many other orphan proteins, could have a viral origin.

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DNA topoisomerase V: a new fold of mysterious origin
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 24, Issue 6, June 2006, Pages 245–247
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering