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Conjugated polyelectrolytes for label-free DNA microarrays

Paper ID Volume ID Publish Year Pages File Format Full-Text
37715 45396 2008 3 PDF Available
Title
Conjugated polyelectrolytes for label-free DNA microarrays
Abstract

Classical strategies for gene microarrays require labeling of probes or target nucleic acids with signaling molecules, a process that is expensive, time consuming and not always reliable. Bazan and colleagues showed that a nucleic acid-binding cationic conjugated polyelectrolyte can be used in label-free DNA microarrays based on surfaces modified with neutral peptide nucleic acid (PNA) probes. This technique provides a simple and sensitive method for DNA detection without the need for covalent labeling of target DNA.

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Conjugated polyelectrolytes for label-free DNA microarrays
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 26, Issue 2, February 2008, Pages 57–59
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering