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Epigenetic stability of embryonic stem cells and developmental potential

Paper ID Volume ID Publish Year Pages File Format Full-Text
37739 45401 2007 7 PDF Available
Title
Epigenetic stability of embryonic stem cells and developmental potential
Abstract

Recent studies highlight the tremendous potential of human embryonic stem (ES) cells and their derivatives as therapeutic tools for degenerative diseases. However, derivation and culture of ES cells can induce epigenetic alterations, which can have long lasting effects on gene expression and phenotype. Research on human and mouse stem cells indicates that developmental, cancer-related genes, and genes regulated by genomic imprinting are particularly susceptible to changes in DNA methylation. Together with the occurrence of genetic alterations, epigenetic instability needs to be monitored when considering human stem cells for therapeutic and technological purposes. Here, we discuss the maintenance of epigenetic information in cultured stem cells and embryos and how this influences their developmental potential.

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Epigenetic stability of embryonic stem cells and developmental potential
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 25, Issue 12, December 2007, Pages 556–562
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us