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Nanoparticles for drug delivery to the lungs

Paper ID Volume ID Publish Year Pages File Format Full-Text
37740 45401 2007 8 PDF Available
Title
Nanoparticles for drug delivery to the lungs
Abstract

The lungs are an attractive route for non-invasive drug delivery with advantages for both systemic and local applications. Incorporating therapeutics with polymeric nanoparticles offers additional degrees of manipulation for delivery systems, providing sustained release and the ability to target specific cells and organs. However, nanoparticle delivery to the lungs has many challenges including formulation instability due to particle–particle interactions and poor delivery efficiency due to exhalation of low-inertia nanoparticles. Thus, novel methods formulating nanoparticles into the form of micron-scale dry powders have been developed. These carrier particles exhibit improved handling and delivery, while releasing nanoparticles upon deposition in the lungs. This review covers the development of nanoparticle formulations for pulmonary delivery as both individual nanoparticles and encapsulated within carrier particles.

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Nanoparticles for drug delivery to the lungs
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 25, Issue 12, December 2007, Pages 563–570
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering