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Selection methods for high-producing mammalian cell lines

Paper ID Volume ID Publish Year Pages File Format Full-Text
37752 45402 2007 8 PDF Available
Title
Selection methods for high-producing mammalian cell lines
Abstract

The selection of high-producing mammalian cell lines represents a bottleneck in process development for the production of biopharmaceuticals. Traditional methods are time consuming (development times often exceed six months) and significantly limited by the number of clones that can be feasibly screened. The market for therapeutic proteins is set to double by 2010, so there is an increasing need to develop methods for the selection of mammalian cell lines stably expressing recombinant products at high levels in an efficient, cost-effective and high-throughput manner. Alternatives include higher throughput methods based on flow-cytometric screening and recently developed automated systems for the selection of high-producing cell lines.

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Selection methods for high-producing mammalian cell lines
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 25, Issue 9, September 2007, Pages 425–432
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us