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Integrated recirculating foam fractionation for the continuous recovery of biosurfactant from fermenters

Paper ID Volume ID Publish Year Pages File Format Full-Text
3784 188 2011 8 PDF Available
Title
Integrated recirculating foam fractionation for the continuous recovery of biosurfactant from fermenters
Abstract

A novel foam fractionation design has been developed for continuously recovering extracellular biosurfactants from fermenters. The apparatus design allows for the operating conditions of the foam fractionation process, feed rate and airflow rate, to be chosen independently of the fermentation parameters. Optimal conditions can then be established for each process, such as the aeration rate required to meet the biological oxygen demand of the cell population. The recirculating foam fractionation process was tested on fed batch fermentations producing the hydrophobin protein HFBII. It is shown that by using foam fractionation to strip HFBII from fermentation broth in situ the amount of uncontrolled overflow from the fermenter was greatly reduced from 770 g to 44.8 g, compared to previous fermentations without foam fractionation. Through optimisation of the foam column operating conditions the proportion of dry matter retained in the fermenter was increased from 88% to 95%, in contrast to dry matter retention of 66% for fermentation without the new design. With the integrated foam fractionation process an HFBII recovery of 70% was achieved at an enrichment of 6.6. This study demonstrates the utility of integrated foam fractionation in minimising uncontrolled foaming in fermenters whilst recovering an enriched product.

Research highlights► A novel foam fractionation column has been developed for biosurfactant recovery. ► Fermentation and foam column operating conditions can be independently optimised. ► Integrated foam fractionation reduced uncontrolled overflow by a factor of 17. ► Optimising the foam separation increased biomass retention from 88% to 95%. ► An HFBII recovery of 70% was achieved at an enrichment of 6.6.

Keywords
Bioseparations; Biosurfactant; Foam fractionation; Downstream processing; Process integration; Yeast
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Integrated recirculating foam fractionation for the continuous recovery of biosurfactant from fermenters
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 54, Issue 2, 15 April 2011, Pages 132–139
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us