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Development of a bovine collagen–apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty

Paper ID Volume ID Publish Year Pages File Format Full-Text
381 40 2012 10 PDF Available
Title
Development of a bovine collagen–apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty
Abstract

The aim of this study was to examine the potential of incorporating bovine fibres as a means of reinforcing a typically brittle apatite calcium phosphate cement for vertebroplasty. Type I collagen derived from bovine Achilles tendon was ground cryogenically to produce an average fibre length of 0.96 ± 0.55 mm and manually mixed into the powder phase of an apatite-based cement at 1, 3 or 5 wt.%. Fibre addition of up to 5 wt.% had a significant effect (P ⩽ 0.001) on the fracture toughness, which was increased by 172%. Adding ⩽1 wt.% bovine collagen fibres did not compromise the compressive properties significantly, however, a decrease of 39–53% was demonstrated at ⩾3 wt.% fibre loading. Adding bovine collagen to the calcium phosphate cement reduced the initial and final setting times to satisfy the clinical requirements stated for vertebroplasty. The cement viscosity increased in a linear manner (R2 = 0.975) with increased loading of collagen fibres, such that the injectability was found to be reduced by 83% at 5 wt.% collagen loading. This study suggests for the first time the potential application of a collagen-reinforced calcium phosphate cement as a viable option in the treatment of vertebral fractures, however, issues surrounding efficacious cement delivery need to be addressed.

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Keywords
Calcium phosphate cement; Collagen fibres; Reinforcement; Vertebroplasty; Injectability
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Development of a bovine collagen–apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 11, November 2012, Pages 4043–4052
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us