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A temperature-shift strategy for efficient arachidonic acid fermentation by Mortierella alpina in batch culture

Paper ID Volume ID Publish Year Pages File Format Full-Text
3813 190 2010 5 PDF Available
Title
A temperature-shift strategy for efficient arachidonic acid fermentation by Mortierella alpina in batch culture
Abstract

Batch culture of Mortierella alpina for arachidonic acid (ARA) production at various temperatures ranging from 15 to 25 °C was investigated. Cell growth showed to be optimum at 25 °C, while ARA accumulation showed to be maximal at 20 °C. Based on time courses of specific cell growth rate and specific ARA formation rate, a temperature-shift strategy, in which the culture temperature was controlled at 25 °C at the first 108 h, and then switched to 20 °C after 108 h, was developed. By applying such a temperature-shift strategy, the dry cell weight increased from 34.7 to 36.7 g/l, and the concentration of ARA increased from 7.3 to 9.2 g/l, increased by 26.1%. This was the first report of using a two-stage temperature-shift strategy in ARA production, and it was proved to be an effective method for optimizing ARA production using this strain.

Keywords
Arachidonic acid; Mortierella alpina; Temperature-shift strategy; Batch fermentation; Kinetic analysis; Lipids
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 53, Issue 1, 15 December 2010, Pages 92–96
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us