fulltext.study @t Gmail

Developing a physiological model for type II diabetes mellitus

Paper ID Volume ID Publish Year Pages File Format Full-Text
3837 192 2011 10 PDF Available
Title
Developing a physiological model for type II diabetes mellitus
Abstract

High blood glucose levels in type II diabetic patients often result from the malfunction of different organs such as the pancreas, the liver, muscles, and adipose tissues. Accurate diagnosis of abnormalities associated with type II diabetic patients is essential for administering an effective treatment. In this paper, a model for type II diabetes has been developed based on a detailed compartmental physiological model proposed for a healthy human body. Using available clinical data from type II diabetic patients, the model parameters have been estimated by means of an optimization method for diabetic patients. The estimated model may be used to understand the behavior of different organs in type II diabetic patients. It has been shown that the proposed model can predict the relative deficiency in the pancreatic insulin production, the impaired hepatic regulatory effect on glucose concentrations, and the low peripheral glucose uptake in type II diabetic patients.

► A detailed compartmental physiological model was developed to represent a patient with type II diabetes mellitus. ► The model parameters were estimated from clinical patient measurements. ► Physiological abnormalities associated with type II diabetes mellitus were simulated. ► The simulated results were found to be clinically consistent with physiological responses of type II diabetic patients.

Keywords
Type II diabetes mellitus; Modeling; Compartmental model; Parameter estimation; Dynamic simulation; Nonlinear optimization
First Page Preview
Developing a physiological model for type II diabetes mellitus
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 55, Issue 1, 15 June 2011, Pages 7–16
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us