Mass transport in a microchannel enzyme reactor with a porous wall: Hydrodynamic modeling and applications
A two-dimensional flow model, incorporating mass transport, has been developed to simulate a microchannel enzyme reactor with a porous wall. A two-domain approach based on the finite volume method was implemented. Two parameters are defined to characterize the mass transports in the fluid and porous regions: the porous Damkohler number and the fluid Damkohler number. For reactions close to first-order type (enzyme reactor), the concentration results are found to be well correlated by the use of a reaction–convection distance parameter which incorporates the effects of axial distance, substrate consumption and convection. The reactor efficiency reduces with reaction–convection distance parameter because of reduced reaction (or flux) due to the lower concentration. Increased fluid convection improves the efficiency but it is limited by the diffusion in the fluid region. The correlated results can find applications for the design of enzyme reactors with a porous wall.
Journal: Biochemical Engineering Journal - Volume 52, Issues 2–3, 15 November 2010, Pages 227–235