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Peroxidase-mediated oxidation of l-dopa: A kinetic approach

Paper ID Volume ID Publish Year Pages File Format Full-Text
3897 197 2010 7 PDF Available
Title
Peroxidase-mediated oxidation of l-dopa: A kinetic approach
Abstract

A kinetic model able to adequately describe the accumulation of p-topaquinone in peroxidase-mediated oxidation of l-dopa was developed, and the rate constants for both enzymatic and non-enzymatic branch were estimated either experimentally or using a computing program for detailed kinetic simulation. It is demonstrated that the accumulation of p-topaquinone in significant amounts occurred in excess of hydrogen peroxide or during auto-oxidation of l-dopa, but changes in the ratio of initial concentrations of the reactants can reduce considerably the production of this intermediate.

Keywords
HRP, horseradish peroxidase; SOD, superoxide dismutase; dl-dopa, (3,4-dihydroxyphenyl alanine); DC, dopachrome; Q, o-dopaquinone-H+; PTQ, p-topaquinone-H+; ROS, reactive oxygen speciesHorseradish peroxidase; Auto-oxidation; l-Dopa; Dopachrome
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 52, Issues 2–3, 15 November 2010, Pages 248–254
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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