Asymmetric reactions of chiral organo-magnetic nanoparticles
•Chiral organocatalysts supported on magnetic nano particles (MNPs) have been divided into five categories and discussed their application towards asymmetric reactions.•The structures of each catalyst, immobilization technique on MNPs, catalytic efficiency and number of reusable cycles have also been discussed as simple as possible for researchers.•Smaller size and high surface area of pseudo-heterogeneous nature of these MNPs lead to excellent loading and high catalytic activity.•Separation of the catalyst from a reaction mixture is very easy and simple by applying with an external magnet.
Magnetic nanoparticles (MNPs) have been widely used as a catalytic supports. MNPs have high surface-area that allows the design and setup of many catalytic sites. Their surfaces can be modified with chiral organocatalyst (COC) to become a sustainable catalytic material. This functionalized magnetite can be easily separated using an external magnet after reaction. We summarize the use of COC-MNPs which are robust and readily available for chiral transformation. The catalytic activity, recyclability, and immobilization method of COC-MNPs are described. The catalytic load, size of the particles, solvent system, ee values and de ratios are also evaluated on each asymmetric reaction.
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Journal: Applied Catalysis A: General - Volume 506, 5 October 2015, Pages 254–260