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A novel immunosensor based on gold nanoparticles and poly-(2,6-pyridinediamine)/multiwall carbon nanotubes composite for immunoassay of human chorionic gonadotrophin

Paper ID Volume ID Publish Year Pages File Format Full-Text
3907 198 2010 7 PDF Available
Title
A novel immunosensor based on gold nanoparticles and poly-(2,6-pyridinediamine)/multiwall carbon nanotubes composite for immunoassay of human chorionic gonadotrophin
Abstract

A novel multilayer film based on gold nanoparticles (GNPs) and poly-(2,6-pyridinediamine)/multiwall carbon nanotubes composite (pPA/MWNTs) was exploited to develop a highly sensitive amperometric immunosensor for detecting human chorionic gonadotrophin (HCG). In this method, pPA/MWNTs composite was prepared by electro-polymerizing PA onto MWNTs modified electrode, and then GNPs were used as a linker to immobilize HCG antibody onto the pPA/MWNTs modified electrode. Cyclic voltammetry (CV) and scanning electron microscopy (SEM) were employed to characterize the assembly process and the performance of the immunosensor. Because of the synergistic effect of pPA and MWNTs, and the unique properties of GNPs, the obtained immunosensor exhibited a wide linear response to HCG in two range from 1.0 to 10.0 and 10.0 to 160.0 mIU mL−1 with a relatively low detection limit of 0.3 mIU mL−1 (S/N = 3), as well as good stability and repeatability.

Keywords
Immunosensor; Multiwall carbon nanotubes; Poly-(2,6-pyridinediamine); Gold nanoparticles; Human chorionic gonadotrophin
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A novel immunosensor based on gold nanoparticles and poly-(2,6-pyridinediamine)/multiwall carbon nanotubes composite for immunoassay of human chorionic gonadotrophin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 51, Issue 3, 15 September 2010, Pages 95–101
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us