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Three-dimensional CFD modelling of a continuous immunomagnetophoretic cell capture in BioMEMs

Paper ID Volume ID Publish Year Pages File Format Full-Text
3909 198 2010 7 PDF Available
Title
Three-dimensional CFD modelling of a continuous immunomagnetophoretic cell capture in BioMEMs
Abstract

Separation of rare cells from blood stream using paramagnetic/superparamagnetic beads in microfluidic device has gained importance in recent years for early diagnosis of several critical diseases. However, the performance of immunomagnetophoretic cell sorters (ICS) crucially depends on their design and operational conditions. Here, we present a three-dimensional CFD model based on the Navier–Stokes equations governing the fluid dynamics and continuum descriptions for the cell, bead and cell–bead complexes for a continuous ICS. The spatial-temporal evolution of the concentration fields are governed by convection–diffusion equations for non-magnetic cells and Nernst–Planck type equations for beads and cell–bead(s) complexes. The attachment rates between cells, cell–bead(s) complexes and beads are deduced from the collision probabilities which are derived by means of classical scattering theory. The CFD model is used to investigate the performance of a generic continuous cell separation system. Since the cells are larger in diameter, more than one bead can get attached to the cells. Multiple beads binding to the cell has been considered in this study, which has not been reported in literature till date. Exemplarily, we investigate the performance of Y-shaped geometry used for contacting of cells and beads.

Keywords
BioMEMs; Cell capture; CFD; Magnetophoresis; Magnetic beads; Continuous sorting
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Three-dimensional CFD modelling of a continuous immunomagnetophoretic cell capture in BioMEMs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 51, Issue 3, 15 September 2010, Pages 110–116
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us