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Model based control of minimal overflow metabolite in technical scale fed-batch yeast fermentation

Paper ID Volume ID Publish Year Pages File Format Full-Text
3933 199 2010 8 PDF Available
Title
Model based control of minimal overflow metabolite in technical scale fed-batch yeast fermentation
Abstract

The specific growth rate should ideally be maintained at maximum oxidative growth rate in order to maximize biomass yield and productivity in fed-batch yeast fermentations. However, a more conservative approach is adopted in industry where specific growth rate is kept below the critical value to prevent the accumulation of overflow metabolite ethanol by using predetermined feeding profiles. In this work, biomass growth is maintained just above maximum oxidative growth rate by regulating ethanol concentration in the fermenter. The state feedback linearizing control strategy is developed and applied to the technical scale fed-batch yeast fermentations. The proposed control algorithm is constructed on the reliable state estimation algorithm developed previously and the biomass concentrations and ethanol measurements are then used in the control algorithm. The ethanol concentration is successfully controlled at fixed and time varying set values. By this approach the specific growth rate is controlled just over the critical value by regulating minimal ethanol concentration in order to maximize the biomass productivity.

Keywords
Nonlinear process; Feedback linearizing control; Fed-batch; Baker's yeast; Ethanol concentration; Biocalorimetry
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Model based control of minimal overflow metabolite in technical scale fed-batch yeast fermentation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 51, Issues 1–2, 15 August 2010, Pages 64–71
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us