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Simplified dynamic pressure method for kLakLa measurement in aerated bioreactors

Paper ID Volume ID Publish Year Pages File Format Full-Text
3942 200 2010 8 PDF Available
Title
Simplified dynamic pressure method for kLakLa measurement in aerated bioreactors
Abstract

A simplified version of the dynamic pressure method for measuring mass-transfer coefficients in gas–liquid systems is proposed. With this method oxygen concentration in the liquid phase is monitored after a sudden change of total pressure is applied to the system. With respect to the original technique introduced by Linek [14] the simplified version here proposed greatly simplifies the data treatment, yet resulting in good accuracy for most practical purposes. In practice, with the help of a simple mathematical model, it is found that the dynamic oxygen concentration response, when plotted as residual driving force versus time in a semi-log   diagram, should be expected to finally settle on a straight line. From the slope of this last kLakLa can be immediately computed. Experimental data obtained on a lab-size stirred tank reactor confirm all model predictions, including the feature that the adoption of large pressure changes may lead to better accuracy. Mass transfer coefficient data obtained by means of the simplified dynamic pressure method   (SDPM) here proposed are compared with the relevant data obtained on the same system by the most accurate physical technique (pure oxygen absorption in a pre-evacuated liquid), as well as with the literature data, resulting in SDPM full validation. All kLakLa data obtained are finally organized by a conventional power law correlation.

Keywords
Dynamic modelling; Gas–liquid mass transfer; Multiphase bioreactors; Oxygen transfer; kLakLa; Stirred vessels
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Simplified dynamic pressure method for kLakLa measurement in aerated bioreactors
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 49, Issue 2, 15 April 2010, Pages 165–172
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us