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Titanium phosphate glass microspheres for bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
395 40 2012 10 PDF Available
Title
Titanium phosphate glass microspheres for bone tissue engineering
Abstract

We have demonstrated the successful production of titanium phosphate glass microspheres in the size range of ∼10–200 μm using an inexpensive, efficient, easily scalable process and assessed their use in bone tissue engineering applications. Glasses of the following compositions were prepared by melt-quench techniques: 0.5P2O5–0.4CaO–(0.1 − x)Na2O–xTiO2, where x = 0.03, 0.05 and 0.07 mol fraction (denoted as Ti3, Ti5 and Ti7 respectively). Several characterization studies such as differential thermal analysis, degradation (performed using a novel time lapse imaging technique) and pH and ion release measurements revealed significant densification of the glass structure with increased incorporation of TiO2 in the glass from 3 to 5 mol.%, although further TiO2 incorporation up to 7 mol.% did not affect the glass structure to the same extent. Cell culture studies performed using MG63 cells over a 7-day period clearly showed the ability of the microspheres to provide a stable surface for cell attachment, growth and proliferation. Taken together, the results confirm that 5 mol.% TiO2 glass microspheres, on account of their relative ease of preparation and favourable biocompatibility, are worthy candidates for use as substrate materials in bone tissue engineering applications.

Keywords
Titanium; Phosphate glass; Microsphere; Bone cells; Tissue engineering
First Page Preview
Titanium phosphate glass microspheres for bone tissue engineering
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 11, November 2012, Pages 4181–4190
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering