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Effect of particle size distribution on the simulation of immobilized enzyme reactor performance

Paper ID Volume ID Publish Year Pages File Format Full-Text
3954 200 2010 8 PDF Available
Title
Effect of particle size distribution on the simulation of immobilized enzyme reactor performance
Abstract

A mathematical model that describes the heterogeneous reaction–diffusion process involved in a batch reactor with immobilized enzyme is presented. The model is based on equations considering reaction and diffusion components including biocatalyst particle size distribution. The reaction system includes the bulk liquid phase containing the dissolved substrate (and products) and the solid biocatalyst phase represented by spherical porous particles carrying the enzyme. The model developed is illustrated for the case of penicillin G hydrolysis with immobilized penicillin acylase, which is a complex reaction system in which both products of reaction and the substrate itself are inhibitors. Significant differences in batch reactor performance simulation are observed when considering biocatalyst particles of a single radius and particle size distribution. The magnitude of these differences is proportional to the dispersion (standard deviation) considered in that size distribution function.

Keywords
Immobilized enzyme; Enzyme kinetics; Penicillin acylase; Penicillin hydrolysis; Diffusional restrictions
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Effect of particle size distribution on the simulation of immobilized enzyme reactor performance
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 49, Issue 2, 15 April 2010, Pages 256–263
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us