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Role of liposome on recognition and folding of oxidized and fragmented superoxide dismutase for its re-activation

Paper ID Volume ID Publish Year Pages File Format Full-Text
4003 203 2009 7 PDF Available
Title
Role of liposome on recognition and folding of oxidized and fragmented superoxide dismutase for its re-activation
Abstract

The behaviors of adsorption and folding of oxidized superoxide dismutase (SOD) fragment on the liposome surface have been studied by varying the type of liposomes. The recognition of the SOD fragment by the liposome was found to be performed, depending on the membrane fluidity, surface charge density and, also, instability of the hydrogen bonds of the liposome surface. The conformational change of the SOD fragment on the liposome membrane was dependent on its adsorption although the variation of their secondary structures was observed. The SOD LIPOzyme (liposome with enzyme-like activity) with high SOD-like activity was obtained by the appropriate control of the recognition and folding of SOD fragment through the suitably-regulated interactions between the liposome and the peptide.

Keywords
Membranome; Membrane stress biotechnology; LIPOzyme; Liposome; Antioxidative enzyme; Recognition
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Role of liposome on recognition and folding of oxidized and fragmented superoxide dismutase for its re-activation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 46, Issue 3, 1 November 2009, Pages 313–319
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us