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Selective removal of Gentamicin C1 from biosynthetic Gentamicins by facilitated pertraction for increasing antibiotic activity

Paper ID Volume ID Publish Year Pages File Format Full-Text
4014 204 2008 6 PDF Available
Title
Selective removal of Gentamicin C1 from biosynthetic Gentamicins by facilitated pertraction for increasing antibiotic activity
Abstract

The less active Gentamicin C1 have been selectively removed from the biosynthetic mixture containing Gentamicins C1, C1a, C2 and C2a by facilitated pertraction with D2EHPA dissolved in dichloromethane as the liquid membrane U-shaped pertraction cell. The pertraction has been analyzed by means of initial and final mass flows, permeability and selectivity factors. The main factors, which control the pertraction selectivity, were identified to be the pH-gradient between the feed and stripping phase, mixing intensity of the aqueous phases and carrier concentration in the membrane phase. The maximum selectivity factor has been recorded for pH 8 of feed phase, pH 3 of stripping phase, rotation speed lower than 100 rpm, and carrier concentration of 10 g/l.

Keywords
Gentamicin; Antibiotic; Bioseparations; Liquid membranes; Liquid–liquid extraction; Pertraction
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Selective removal of Gentamicin C1 from biosynthetic Gentamicins by facilitated pertraction for increasing antibiotic activity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 42, Issue 1, 15 October 2008, Pages 28–33
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us