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Separation and purification of (−)schisandrin B from schisandrin B stereoisomers

Paper ID Volume ID Publish Year Pages File Format Full-Text
4018 204 2008 6 PDF Available
Title
Separation and purification of (−)schisandrin B from schisandrin B stereoisomers
Abstract

Schisandrin B (Sch B), consisting of a mixture of its stereoisomers, namely (−)Sch B and (±)γ-schisandrin, is the most abundant and biologically active dibenzocyclooctadiene lignan present in Fructus Schisandrae (FS). The objective of this study is to develop a process for large-scale separation and purification of a single stereoisomer of Sch B, (−)Sch B, which offers the highest desirable bioactivities. To this end, a crystallization-based separation and purification process has been conceptualized. Bench-scale crystallization experiments guided by experimental solid–liquid equilibrium phase diagrams were performed to verify process feasibility. A (−)Sch B product with a purity of 98.5 wt% and a (±)γ-schisandrin-enriched product with a purity of 65.0 wt% were obtained. The (−)Sch B product caused a 32% increase in cellular glutathione level and the (±)γ-schisandrin-enriched product a 26% increase, indicating a potentially more efficacious pharmaceutical preparation.

Keywords
Separation; Purification; Stereoisomers; Crystallization; Process integration; Bioprocess design
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Separation and purification of (−)schisandrin B from schisandrin B stereoisomers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 42, Issue 1, 15 October 2008, Pages 55–60
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us