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Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water

Paper ID Volume ID Publish Year Pages File Format Full-Text
40481 45855 2013 4 PDF Available
Title
Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water
Abstract

A sustainable three-component reaction of indoles, aldehydes, and malononitrile in water promoted by polyethylene glycol (PEG-200) afforded 3-indole derivatives in good to excellent yields.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (136 K)Download as PowerPoint slideHighlights► A sustainable protocol for synthesis of 3-indole derivatives was established. ► Reaction of indoles, aldehydes, malononitrile was promoted by PEG-200 in water. ► The metal catalysts such as copper or indium are not required in this protocol. ► The reaction media can be reused four times without erosion of the yield. ► The target products often can be easily isolated by simple filtration.

Keywords
Green chemistry; Multicomponent reaction; Aldol reaction; Michael addition
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Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water
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Publisher
Database: Elsevier - ScienceDirect
Journal: Applied Catalysis A: General - Volume 454, 15 March 2013, Pages 160–163
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
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Price was $35.95
You save - $31
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