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Modelling and simulation of a transketolase mediated reaction: Sensitivity analysis of kinetic parameters

Paper ID Volume ID Publish Year Pages File Format Full-Text
4111 209 2009 9 PDF Available
Title
Modelling and simulation of a transketolase mediated reaction: Sensitivity analysis of kinetic parameters
Abstract

In this paper we have used a proposed mathematical model, describing the carbon–carbon bond formation reaction between β-hydroxypyruvate and glycolaldehyde to synthesise l-erythrulose, catalysed by the enzyme transketolase, for the analysis of the sensitivity of the process to its kinetic parameters. The model was validated with experimental data. As a conclusion, kinetic parameters with a possible positive impact on reaction performance were identified and assessed in relation to operating conditions. This resulted in the identification of suitable catalyst and process development targets.

Keywords
Mathematical modelling; Biocatalysis; Kinetics; Sensitivity analysis; Enzyme; Transketolase
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Modelling and simulation of a transketolase mediated reaction: Sensitivity analysis of kinetic parameters
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 47, Issues 1–3, 1 December 2009, Pages 1–9
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us