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Engineering cytokine receptors to control cellular functions

Paper ID Volume ID Publish Year Pages File Format Full-Text
4148 211 2010 12 PDF Available
Title
Engineering cytokine receptors to control cellular functions
Abstract

Cytokine receptors function as an interface between a cell and the extracellular milieu, and play a pivotal role in cell fate, because they recognize specific ligands via their extracellular domain and trigger signal transduction via their intracellular domain. Recent advances in unraveling the mechanism of cytokine receptor-mediated signal transduction have allowed us to engineer cytokine receptors with distinct functions, which have a potential for use in biotechnology. This paper reviews the history and current topics of receptor engineering.

Keywords
Chimeric protein; Cytokine; Growth factor; Receptor; Signal transduction
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Engineering cytokine receptors to control cellular functions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 48, Issue 3, 15 February 2010, Pages 283–294
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us