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Tissue transplantation by stealth—Coherent alginate microcapsules for immunoisolation

Paper ID Volume ID Publish Year Pages File Format Full-Text
4153 211 2010 11 PDF Available
Title
Tissue transplantation by stealth—Coherent alginate microcapsules for immunoisolation
Abstract

Several of today's most prominent diseases arise as a result of aberrant secretory or enzymatic function, or loss of the corresponding tissue. While an obvious approach to treating these diseases is to simply replace the malfunctioning, damaged, or lost tissue, the need to immunosuppress recipients places them at increased risk of pathogenic infection and development of cancer. Limited availability of donor tissue is also problematic, and while xenogenic tissue could be used in some instances, immunosuppression alone is insufficient to prevent rejection. As an alternative, a physical barrier could be employed to mask the implanted tissue from immune surveillance at a local level, without the need for systemic immunosuppression. This approach is embodied through tissue microencapsulation. We review the underlying rationale of alginate based tissue microencapsulation technologies, current challenges, and possible solutions to these challenges in the form of a simple emulsion coating system incorporating functionalized alginate for local immunomodulation.

Keywords
Encapsulation; Alginate; Transplant; Cell therapy; Emulsion; Membranes
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Tissue transplantation by stealth—Coherent alginate microcapsules for immunoisolation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 48, Issue 3, 15 February 2010, Pages 337–347
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us