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Protective effect of disubstituted diaryl diselenides on cerebral oxidative damage caused by sodium nitroprusside

Paper ID Volume ID Publish Year Pages File Format Full-Text
4202 214 2009 6 PDF Available
Title
Protective effect of disubstituted diaryl diselenides on cerebral oxidative damage caused by sodium nitroprusside
Abstract

Disubstituted diaryl diselenides, a class of organoselenium compounds, were investigated for antioxidant activity in rat brain homogenates. Diphenyl diselenide (PhSe)2, m-trifluoromethyl-diphenyl diselenide (m-CF3–C6H4Se)2, p-chloro-diphenyl diselenide (p-Cl–C6H4Se)2 and p-methoxyl-diphenyl diselenide (p-CH3O–C6H4Se)2 were tested against lipid peroxidation (LP) induced by sodium nitroprusside (SNP) or malonate and oxidatively modified proteins (OP) induced by SNP in vitro. Disubstituted diaryl diselenides protected against LP and OP. Disubstituted diaryl diselenides were investigated against oxidative damage caused by SNP in mouse brain. Mice were pre-treated with disubstituted diaryl diselenides (25 mg/kg, oral route, p.o.) and subsequently received SNP (0.35 μM/site i.c.v.). The levels of LP and OP, and activities of catalase, δ-aminolevulinate dehydratase (δ-ALA-D) and Na+, K+-ATPase were evaluated in vivo. All disubstituted diaryl diselenides protected against the increase of LP and OP induced by SNP, while only (PhSe)2 and (m-CF3–C6H4Se)2 were able to protect against δ-ALA-D and Na+, K+-ATPase inhibition induced by SNP. In conclusion, (p-Cl–C6H4Se)2 and (m-CF3–C6H4Se)2 were most efficient against lipid and protein oxidation in rat brain homogenates in vitro. All disubstituted diaryl diselenides protected against oxidative damage caused by the administration of SNP in mice in vivo.

Keywords
Disubstituted diaryl diselenides; Selenium; Oxidative stress; Brain; Sodium nitroprusside; Antioxidant
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Protective effect of disubstituted diaryl diselenides on cerebral oxidative damage caused by sodium nitroprusside
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 45, Issue 2, 15 July 2009, Pages 94–99
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us