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Highly enantioselective Ru-catalyzed asymmetric hydrogenation of β-keto ester in ionic liquid/methanol mixtures

Paper ID Volume ID Publish Year Pages File Format Full-Text
42856 45944 2009 7 PDF Available
Title
Highly enantioselective Ru-catalyzed asymmetric hydrogenation of β-keto ester in ionic liquid/methanol mixtures
Abstract

The enantioselective hydrogenation of methyl acetoacetate (MAA) was studied in detail using a ruthenium-monodentate binaphthophosphepine complex in a homogeneous solution formed by different ionic liquids and methanol. Remarkably, ionic liquid additives did not only open an attractive way for catalyst recycling in repetitive batch-mode but also led to significantly increased catalytic activity compared to pure methanol. Enantioselectivities up to 95% have been achieved in mixed ionic liquid/methanol systems which are comparable to the values obtained in pure methanol.

Graphical abstractA group of ionic liquids, which increase the activity of a ruthenium-phenyl-4,5-dihydro-3H-dinaphtho[2,1-c;1′2′-e]phosphepine complex, was identified, synthesized and applied as co-solvent in the asymmetric hydrogenation of MAA in methanol. In these systems the enantioselectivities were found to be in the same range like for pure methanol reaching typical values of 90–96%.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Asymmetric catalysis; Hydrogenation; Ketones; Keto ester; Ionic liquid
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Highly enantioselective Ru-catalyzed asymmetric hydrogenation of β-keto ester in ionic liquid/methanol mixtures
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Publisher
Database: Elsevier - ScienceDirect
Journal: Applied Catalysis A: General - Volume 364, Issues 1–2, 31 July 2009, Pages 8–14
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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