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Selective synthesis of p-cresol by methylation of phenol

Paper ID Volume ID Publish Year Pages File Format Full-Text
43011 45951 2008 9 PDF Available
Title
Selective synthesis of p-cresol by methylation of phenol
Abstract

The selective synthesis of p-cresol by gas-phase alkylation of phenol with methanol was studied on SiO2–Al2O3 and zeolites HBEA, HZSM5 and HMCM22. Cresols were formed from phenol alkylation of methanol via two parallel pathways: the direct C-alkylation of phenol and the conversion of anisole intermediate obtained by O-alkylation of phenol. Methylation of o- and p-cresol led to the formation of 2,6- and 2,4-xylenols while anisole produced methylanisoles either by alkylation with methanol or by disproportionation. Regarding the cresol isomers distribution, p- and o-cresol were the major products on all the samples while m-cresol formation remained always lower than 6%. SiO2–Al2O3, HBEA and HZSM5 exhibited similar initial p-cresol:o-cresol ratios, between 0.6 and 0.8. In contrast, p-cresol was the predominant product on HMCM22 because the narrow sinusoidal 10-membered ring channels of this zeolite were particularly suitable for improving by shape selectivity the formation of p-cresol. Thus, we report here that p-cresol yields of 55% and p-cresol:o-cresol ratios of 4 are obtained on HMCM22 by gas-phase alkylation of phenol with methanol at 473 K, atmospheric pressure and contact time of 350 g h/mol phenol.

Graphical abstractThe selective synthesis of p-cresol by gas-phase alkylation of phenol with methanol was studied on SiO2–Al2O3 and zeolites HBEA, HZSM5 and HMCM22. The p-cresol yield and the para-/ortho-cresol ratio on HMCM22 for 93% phenol conversion were about 58% and 3.4, respectively, the highest values reported up to now for the p-cresol formation from methylation of phenol.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
p-Cresol synthesis; Fine chemicals; Zeolite HMCM22; Phenol methylation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Applied Catalysis A: General - Volume 342, Issues 1–2, 30 June 2008, Pages 40–48
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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Any Questions? feel free to contact us