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Sonocatalysis and zeolites: An efficient route to prepare N-alkylimidazoles: Kinetic aspects

Paper ID Volume ID Publish Year Pages File Format Full-Text
43047 45952 2008 6 PDF Available
Title
Sonocatalysis and zeolites: An efficient route to prepare N-alkylimidazoles: Kinetic aspects
Abstract

The synthesis of N-substituted imidazoles via alkylation of imidazole with 1-bromobutane using sonochemical and thermal activations over zeolites (H-ZSM-5, Mordenite, H-Beta and H-Y) is reported. The effect of the acidity and channel size of zeolites on the activity and selectivity of imidazole alkylation was investigated in a liquid phase. The N-alkylimidazoles are important intermediates in the synthesis of pharmaceuticals with antiviral properties. N-alkylimidazoles were obtained in high yields (>80%) as main product (100% selectivity) under mild conditions, ultrasound (US) activation at 333 K in only 1 h, when Mordenite and NH4Y zeolites were used as catalysts.

Graphical abstractThe kinetic of imidazole alkylation with 1-bromobutane (sonochemical vs. thermal activations) over zeolites (H-ZSM-5, Mordenite, H-Beta and H-Y) is reported. Acidity and channel size of zeolites affect activity and selectivity of imidazole alkylation. Mordenite and NH4Y zeolites produce N-alkylimidazoles in high yields (>80%) and 100% selectivity under mild conditions, ultrasound activation at 333 K in only 1 h. Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
N-alkylimidazoles; Acid zeolites; Sonocatalysis; Green chemistry; Kinetic aspects
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Sonocatalysis and zeolites: An efficient route to prepare N-alkylimidazoles: Kinetic aspects
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Publisher
Database: Elsevier - ScienceDirect
Journal: Applied Catalysis A: General - Volume 338, Issues 1–2, 1 April 2008, Pages 130–135
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us