fulltext.study @t Gmail

Acetone to MIBK process optimization through multidisciplinary chemometrics and in-line NIR spectroscopy

Paper ID Volume ID Publish Year Pages File Format Full-Text
43096 45955 2008 10 PDF Available
Title
Acetone to MIBK process optimization through multidisciplinary chemometrics and in-line NIR spectroscopy
Abstract

A comprehensive experimental approach to the optimization of the process parameters for the production of methyl-isobutyl-ketone (MIBK) from acetone was developed and successfully implemented. This includes conventional laboratory analysis, in-line near infrared (NIR) spectroscopy (with associated principle component analysis) and statistical interpretation of the experimental results. The effect of temperature, pressure, feed rate and the H2 to acetone molar ratio on several responses, i.e. acetone conversion, MIBK selectivity, MIBK yield and in particular MIBK productivity, was investigated on a continuous bench scale reactor system. Using experimental design methodology, empirical models were developed that describe each response as a function of the significant variables, enabling optimization of the process. The MIBK productivity model was validated with an independent experiment. In this paper the use of multidisciplinary chemometric techniques is demonstrated for the attainment of substantial industrial improvements. It is shown that the acetone to MIBK productivity is improved by 30% through operating at a higher pressure and feed rate, provided that the appropriate H2 to acetone molar ratio is used. It was further shown that there is good agreement between the predictions of the response surface model derived from NIR-based transient catalysis testing, and conventional steady state results.

Graphical abstractThe optimization of process parameters for the production of methyl-isobutyl-ketone (MIBK) from acetone over a commercial palladium-doped acidic resin catalyst was undertaken. Conversion, selectivity, yield and productivity were investigated on a continuous bench scale reactor system. Multidisciplinary chemometric techniques are demonstrated for the attainment of substantial industrial improvements and through in-line NIR spectroscopy, transient catalysis testing is made feasible.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Chemometrics; Experimental design; Methyl-isobutyl-ketone synthesis; NIR spectroscopy
First Page Preview
Acetone to MIBK process optimization through multidisciplinary chemometrics and in-line NIR spectroscopy
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Applied Catalysis A: General - Volume 344, Issues 1–2, 15 July 2008, Pages 20–29
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us