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Synthesis, characterization and MRI application of dextran-coated Fe3O4 magnetic nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
4338 221 2008 11 PDF Available
Title
Synthesis, characterization and MRI application of dextran-coated Fe3O4 magnetic nanoparticles
Abstract

Biocompatible ferrofluid based on dextran-coated Fe3O4 magnetic nanoparticles (MNPs) was prepared through a one-step method. In contrast to the conventional co-precipitation method, hydrazine hydrate was added as reducing agent and precipitator in the present investigation. The effects of hydrazine hydrate, the weight ratio of dextran to MNPs and the molecular weight of dextran on the dispersibility of MNPs in water were investigated. Also, the particles size of modified MNP and coating efficiency of dextran on MNPs were measured. In addition, biocompatible ferrofluid was intravenously injected into rabbits, the iron content in blood and organs at different times were measured by atomic absorption spectrometer, and the bio-distribution and the bio-transportation of ferrofluid in organs was examined. Then, the magnetic resonance (MR) images of liver, marrow and lymph were acquired by MRI experiments before and after intravenous injection of ferrofluid. Image analysis revealed that the MR signal intensity of these organs notably decreased after intensified by ferrofluid. However, when there existed tumors in organs, the signal intensity of tumor did not change after injection. From that the tumor can easily be identified, which indicated a potential application of the as-prepared MNP in functional molecular imaging for biomedical research and clinical diagnosis.

Keywords
Magnetic nanoparticles; Dextran; Bioprocess monitoring; Rheology; Animal cell culture; MRI
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Synthesis, characterization and MRI application of dextran-coated Fe3O4 magnetic nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 42, Issue 3, 1 December 2008, Pages 290–300
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us